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Weed Killers to Get Rid of Weeds Fast for Large Areas

Jelena Maric
Agricultural Engineer

Why weeds are a problem

Weeds can be quite a problem. They can suck up nutrients from the soil and may also attract insects, which will eat your flowers or vegetables. Additionally, weeds can impact the aesthetics of your property, making it look less attractive. You don't want your lawn to have patches of green in it when you could have a lush green lawn with no weeds. A safe approach to a weed problem is also extremely important, because many weed killers are toxic, and are not the best fit for treating flower beds, or any area close to people.

How to Choose the Best Weed Killer for large areas

One of the most important steps in controlling weeds is choosing the right weed killer.

Many homeowners will use any old brand of weed killer when they're trying to get rid of the weeds in their flower beds. Weed killers are a necessary part of any gardener's toolkit, but not all weed killers are created equal. So what is the best type to choose? 

The answer can be different, depending on specific needs and circumstances. There isn't one "best" solution like many people assume there might be.

What is the Best Weed Killer for Large Areas?

Some of the best weed killers for large areas are based on the type of weed you need to kill. For example, if you have a lot of broadleaf weeds in your garden, you'll want to use a product that targets those types of weeds and nothing else. You may also want to consider using an organic weed killer like vinegar and dish soap. This natural solution will clear away all the weeds without damaging other plants in the area.

Many people who try to get rid of weeds end up with tough spots where the roots are still alive. Try to apply your weed killer about two weeks after the first application to avoid this problem. Doing this will help ensure that all the roots are killed and that no more weeds are growing in that area.

The 4 Best Commercial Weed Killers for Large Areas

Roundup Max Plus Weed and Grass Killer

Roundup kills tough weeds to the root. It provides visible results as fast as 9 hours with its FastAct Technology. The product can be used on large areas, as well as in small spaces.

Apply it using a Roundup brand tank sprayer. Just spray the plants you want to eliminate until they are thoroughly wet. Avoid desirable plants and rinse with water if accidentally sprayed. Weeds begin to wilt within days and die within one or two weeks, plus there is no need for waiting long before replanting. You can plant flowers one day after spraying your weeds with this product.

Active ingredients in Roundup are all extremely toxic to humans and animals if they come into contact with them in any way. Always wear your protective clothing when applying Roundup to avoid coming into contact with it yourself or having your pets come into contact with it as well. If you do accidentally get some on you or your pet, wash it off immediately before it has a chance to absorb through your skin.

Spectracide 96451 HG-96451 Weed & Grass Killer Concentrate2

Spectracide is a non-selective weed and grass killer that will kill both the weeds and roots

This product is designed to be easy to use - pour it on and walk away. It's a good idea to wear gloves and eye protection while using this product, as it can burn skin and irritate eyes. 

It can also kill some plants you want to keep, so be sure to read all precautions before applying this product.

This weed killer is a good choice for people who want an herbicide that kills weeds fast and effectively. It's also great for people who don't have a lot of time on their hands or don't want to worry about mixing chemicals.

Compare-N-Save 75324 Herbicide

For best results, apply it when the temperature is at least 60°F, and there is no rain in the forecast within 24 hours. It is recommended spot spraying for weed control of perennials or brushes. 


Mix 1/2 ounce (1 tablespoon) with one gallon of water for general weed control or 2 ounces (4 tablespoons) per gallon to kill tough weeds such as perennial plants or brush. One ready-to-use product will cover 300 square feet but if you need more coverage, mix 2 gallons at a time to cover an area twice the size. Glyphosate is absorbed through foliage travels straight to root, killing plants. Be sure not to spray anywhere else, other than what you want to be treated, as it can cause irreversible damage.

Fertilome 33692 Killzall Weed and Grass Killer

Contains a double-surfactant formulation that dries quickly to start working immediately. You can cover and treat large areas (32 oz bottle of weed control liquid concentrate covers up to 6,400 square feet). 32 ounces will last for one application or two smaller applications as needed. Spray directly onto undesirable plants/weeds in flower beds etc., when the air is calm (spraying accessory required). Wait 1 day after spraying before planting your desired vegetation. 

If using on taller than 5-foot plants, cut back plant first, then apply weed killer product according to package directions. 

How to Use Weed Killers

Weed killers come in many forms. Some you spray from a can, while others are made to be sprayed on the ground near the weed. The best time to use a weed killer is when weeds are small and young. They will die more quickly and easily this way than if they are older. Be sure to wear gloves and protective eyewear when using weed killer, so you do not get it on your skin or in your eyes.

Tips for Spraying Large Areas of Weeds

  • Spray the weeds in one direction, spraying in a back and forth motion. - Make sure you're spraying the weed's leaves, not the ground around it. - Try spraying different areas of the weed to see if one area is more susceptible to killing than another. - Use a gentle spray so you don't damage nearby plants or flowers. - If you're using a backpack sprayer, make sure you're holding it at the right height. - Spray in the early morning or late afternoon to avoid damaging plants that are sensitive to sunlight.
  • If you use a pump sprayer, make sure the nozzle is on fine mist and not stream.
  • Make sure you don't spray when it's too windy because it could damage your plants or flowers.
  • Try spraying when there isn't any rain in the forecast because it could wash away your herbicide before it has a chance to do any damage.
  • Only spray your weeds when they're actively growing.
  • Make sure you don't use the same herbicide on your plants and weeds because it could kill them, too.
  • If you notice that one of your plants is damaged by the herbicide, try watering it with a solution of vinegar and water to neutralize the chemical.
  • Don't spray for weeds in areas where you're trying to grow grass or other vegetation.
Check The Weather Forecast of Next few days in your area by clicking in the picture below
Weather forecast before applying weed killer in large area


Weeds can be difficult to manage, but the right weed killer can make the job much easier. When it comes to weeds, what you don’t want is a product that’s only effective on small areas of weeds or that only kills the green parts of a weed. You want a product that will kill the entire weed, right down to the root.

An easy way to find a weed killer that will work for your garden is to read reviews. Most people will have tried a variety of products and can tell you which are the best. And if you see a product recommended by many people, then it’s likely to be a good choice.

It’s also important to note that different weed killers kill weeds in different ways. Some are better for weeds in the ground and others are better for weeds in containers. Knowing which type of weed killer you’re using will help you get rid of weeds much faster.

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